by Donald J.Abraham

This new sixth edition of Burger’s Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.

With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger’s Medicinal Chemistry and Drug Discovery includes more than 50ew material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:
* Proteomics
* Genomics
* Bioinformatics
* Combinatorial Chemistry
* High-Throughput Screening
* Blood Substitutes
* Allosteric Effectors as Potential Drugs
* COX Inhibitors
* Statins
* High-Throughput Pharmacology
* and More.

The new sixth edition of Burger’s Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as “Medicinal Chemistry” in two volumes in 1951. Dr. Burger’s research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger’s contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.

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Description:
Medicinal Chemistry: A Molecular and Biochemical Approachscreen.width*0.7) {this.resized=true; this.width=screen.width*0.7; this.alt=’Click here to open new window’;}” border=0>ISBN: 0195104560Title: Medicinal Chemistry: A Molecular and Biochemical ApproachAuthor: Thomas Nogrady, Donald F. WeaverPublisher: Oxford University Press, USA (2005)Publication Date: 2005-07-28Number Of Pages: 672Average Amazon Rating: 5.0Book Id 35280Editorial DescriptionFully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design.

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John Mann “Life Saving Drugs: The Elusive Magic Bullet”
Published by Royal Society of Chemistry November 2004 ISBN : 0854046348 PDF Format, 234 pages English 15.2 MB

In 1900 only a handful of drugs (morphine, quinine, aspirin etc) had genuine efficacy and recovery from infections was haphazard. Now there are literally thousands of drugs and life-threatening infections have been either overcome or much diminished.
Life-saving Drugs: the Elusive Magic Bullet describes the discovery and development of antibacterial, anti-viral and anti-cancer drugs. The book highlights the colourful characters behind the inventions and the huge improvements in quality of life and life-expectancy that these drugs have produced.

Emphasis is given to the new drugs that have emerged as a result of knowledge of the human genome, and the ways in which the newer drugs are being designed to tackle disease, particularly cancer, at the genetic level. Chemical structures are provided for all of the key drugs and the book is well illustrated.

Life-saving Drugs: the Elusive Magic Bullet can be read as a history of drug development during the past 100 years by those with only a passing knowledge of chemistry. For anyone entering the medical profession, pharmacy, or nursing, it will provide a superb basic knowledge of all drugs they are ever likely to meet, including their modes of action. For the chemist or medicinal chemist, it will provide the fundamental knowledge of life-saving drugs that they all should know. And for the non-scientist who wants to know about ’super-bugs’, SARS, Ebola, and all of the wonderful advances in treating cancer, it is illuminating and easy to read.

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`Review from previous edition …presents a complex subject in a clear, readable manner. In places, it even manages to be amusing.’ New Scientist`… informative, easy to read and the illustrations are particularly instructive … mathematical principles are handled sympathetically and with more clarity than I have seen elsewhere … this is a well produced, informative and readable book, and provides excellent value for money.’ Education in Chemistry, November 1995″(The book is distinguished by) Professor Glenn’s enormous breadth of knowledge about the great legal traditions of the world…the genuine effort towards an understanding of other cultures, and the great capacity of the author to express (himself) clearly and directly.” Verfassung und Recht in Ubersee Summer 2001″Of interest not only to students of law, but to anyone concerned with intercultural dialogue.” Verfassung und Recht in Ubersee Summer 2001″This book can be warmly recommended to students as an affordable introduction to medicinal chemistry”. The Royal Society of Chemistry, 2002.”Through appropriate graphics and very good explanations, this book allows the student to acquire a sound understanding of the development of medicines, even without having a previous strong grounding in biochemistry.” Reto Mueller, Organische Chemie. Book DescriptionNEW TO THIS EDITION Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * adrenergics * drug discovery and drug development An Introduction to Medicinal Chemistry

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by Ashutosh kar

Medicinal ChemistryPublisher: New Age International English ISBN: 9788122423057 960 pages 2007 PDF 31 Mb

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HOW DRUGS ACT AND WHY

BY :Alex

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Medicinal Chemistry of Bioactive Natural Products by Xiao-Tian Liang (Editor), Wei-Shuo Fang (Editor)[REPOST]
Publisher: Wiley (March 10, 2006) ISBN: 0471660078 PDF 5,3 Mb 460 pages

Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world’s leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies-developed for natural products-with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.

Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.

Enhanced by examples with updated research results, the discussion covers such topics as:
* The chemistry and biology of epothilones
* Vancomycin and other glycopeptide antibiotic derivates
* Antitumor and other related activities of Taxol and its analogs
* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
* Huperzine A: A natural drug for the treatment of Alzheimer’s disease
* The medicinal chemistry of ginkgolides from Ginkgo biloba
* Recent progress in Calophyllum coumarins as potent anti-HIV agents
* Plant-derived anti-HIV agents and analogs
* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

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