Targeted Radionuclide Tumor Therapy: Biological AspectsPublisher: Springer Language: English ISBN:1402086954 402 pages Data: 2007 PDF 5 Mb

Description:
The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title of this book “Targeted Radionuclide Tumor Therapy – Biological aspects” was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effects, different types of cell death, autosensitization and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.The development of targeted therapy is a true multidisciplinary enterprise involving physician scientists from the fields of nuclear medicine, radiation therapy, diagnostic radiology, surgery, gynaecology, pathology and medical oncology/haematology. It also involves many preclinical scientists working with experimental animal models, immunochemistry, recombinant antibody technologies, radiochemistry, radiation physics and basic cell biology.It is the ambition of the editors to enable deeper insights in the process of improving targeted therapy. We believe that the time now has come when targeted therapy can soon be added to standard oncology treatment regimens.

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Description: Offering lower toxicity and higher accuracy than conventional therapies, this source offers illustrative coverage of this new method to treat tumors associated with brain, breast, lung, and neuroendocrine cancers. Accompanied by a CD offering color images, radiolabeling procedures, and tips on radiopharmceutical administration, this source will offer comprehensive and expert guidance on this burgeoning therapeutic technique.

This is the classic text/reference of nuclear pharmacy, thoroughly updated and judiciously expanded. Generously supplemented with charts, tables, and more than 100 illustrations throughout, each chapter provides the reader with well-delineated descriptions, from the basic autotomic structure through the clinical uses of radiopharmaceuticals. Previous editions were unanimously priased for their clarity and accuracy, as Dr. Saha set new standards for making complex theoretical concepts readily understandable for students and practitioners in nuclear pharmacy and nuclear medicine. New features in the Fourth Edition include: – up-to-date descriptions of the latest NRC and FDA regulations – clinical uses of all new radiopharmaceuticals and techniques, including those radiopharmaceuticals having the potential for clinical use – quality control data for all new radiopharmaceuticals – dosimetry data for all new radiopharmaceuticals – an entire new chapter devoted to the therapeutic uses of radiopharmaceuticals – an upgraded section on 99mTc chemistry – addition to the 62Zn-62Cu generator in th chapter on “Radionuclide Generators” – latest developments in brain, heart, and tumor imaging – a new section on parathyroid imaging From reviuews of the Third Edition: “¿the strengths of this edition, coupled with its currentness, make this book today’s frontrunner among introductory radiopharmacy texts.” -Clinical Nuclear Medicine “¿an excellent overview of all different aspects of nuclear pharmacy¿consistent, well-written, concise¿. I can recommend it as a reference in nuclear pharmacy and as a textbook for nuclear medicine technologists.” -European Journal of Nuclear Medicine

Radioisotope therapy is an internal form of radiation used to treat cancer; it may be administered orally or intravenously and represents the nearest treatment option to the ‘magic bullet’, specifically targeting sites of disease whilst sparing surrounding normal tissues.Radioisotope therapy has an important role to play in modern medicine, particularly in the treatment of thyroid disease, neuroendocrine tumours, bone metastasis and non-Hodgkin’s lymphoma. It is found in both the diagnostic setting and in therapy, but recently there has been a renaissance in the application of radioisotope unsealed sources in therapeutic indications. It is an active area of research, with the quest for new compounds that will be specific for therapeutic targets. This book is an essential, practical guide to the use of radioisotope therapy, and also includes the background and developmental biology which underpins its use. Individual tumours and diseases are explored, with specific focus given to radioisotope treatment options. The barriers to radioisotope therapy, such as ease of access, acquisition of radioisotopes, radiation protection regulations, and cost are also discussed. ABOUT THE SERIES Radiotherapy remains the major non-surgical treatment modality for the management of malignant disease, with over 50% of patients receiving treatment at some time during the management of their malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in this series takes the reader through the basic principles of different types of radiotherapy, and then develops these by individual sites. This series of practical handbooks are aimed at physicians both training and practising in radiotherapy, as well as medical physicists, dosimetrists, radiographers and senior nurses.