Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Continue Reading »
Pharmacokinetics in Drug Discovery and Development

Extends the concepts of Volume 1 to include drug properties, design and optimization, coating and the effect of food and pharmacokinetics. This volume also reflects the growing interest in biodegradable polymers in oral and topical formulations.

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This book is divided into two parts; in the first part the principles and the methods of pharmacokinetics are described in detail, while in the second the main pharmacokinetic parameters are described, giving for each of them the definition, the principal properties, and the methods of determination. An appendix contains the important mathematical instruments used in the main part of the book, namely the operational calculus and the convolution integral.

The first part begins with the definition of pharmacokinetics, then continues with the description of the experimental method as applied to the modeling of pharmacokinetic systems. The bulk of this part is the description of the first compartmental models used in the ’30’s, the more modern compartmental equations developed later, the integral equations and the matrix equations. Continue Reading »
Foundations of Pharmacokinetics

Computational Pharmacokinetics (Chapman & Hall/Crc Biostatistics Series)
By Anders Kallen

Publisher: Chapman & Hall/CRC
Number Of Pages: 184
Publication Date: 2007-07-19
ISBN-10 / ASIN: 1420060651
ISBN-13 / EAN: 9781420060652
Binding: Hardcover

Being that pharmacokinetics (PK) is the study of how the body handles various substances, it is not surprising that PK plays an important role in the early development of new drugs. However, the clinical research community widely believes that mathematics in some way blurs the true meaning of PK. Continue Reading »
Computational Pharmacokinetics

Concepts In Clinical Pharmacokinetics
Publisher:American Society of Health-System Pharm Pages:230 2005-10-30 ISBN:1585281247 CHM 2.1 MB
Programmed manual presents basic pharmacokinetic concepts and procedures. Material relates to individualization of drug dose regimens. Continue Reading »
Concepts In Clinical Pharmacokinetics